5 Best Weed Killer for Large Areas: How to Get Rid of Pesky Weeds

Weeds are the nastiest, and it’s necessary to use the best weed killer for large areas before they get out of control and take over the lawn. Besides being aesthetically unappealing, weeds are also primary reasons for crop yield loss and unhealthy grass and plants.

RM43 43-Percent Glyphosate Plus Weed Preventer Total...
5,922 Reviews
RM43 43-Percent Glyphosate Plus Weed Preventer Total...
  • Kills weeds and prevents weeds for up to 1 year
  • Treats 17,297 square feet
  • Ideal for fence rows, gravel paths, sidewalks, driveways,...

It’s challenging to find an effective weed killer to cover large lawns with many brands around, but the RM43 Total Vegetation Control does the job swiftly. It boasts the highest Glyphosate concentration in commercially available herbicides. It can destroy all types of weeds and unwanted grass in driveways, patios, pathways, and fences.

Plus, a gallon of this highly potent concentrate is enough to treat more than 17,000 square feet. Another reason to buy this weed killer is it keeps those lawn invaders away for at least an entire year, ideal for keeping the garden pristine for an extended time.

Weed Killer for Large Areas

Best Weed Killer For Large Areas Review

RM43 43% Glyphosate Plus Total Vegetation Control

RM43 43-Percent Glyphosate Plus Weed Preventer Total...
5,922 Reviews
RM43 43-Percent Glyphosate Plus Weed Preventer Total...
  • Kills weeds and prevents weeds for up to 1 year
  • Treats 17,297 square feet
  • Ideal for fence rows, gravel paths, sidewalks, driveways,...


  • Type – Non-selective herbicide (total vegetation control)
  • Capacity – 1 Gallon
  • Coverage – 17,297 square feet
  • Coverage period – up to 1 year
  • Active ingredient – 43% Glyphosate
  • Ideal against: weeds, vines, brushes
  • Ideal for: driveways, gravel paths, sidewalks, fence rows, parking areas

What We Like

It’s already in the name, and it’s impressively appealing that this herbicide does what it got designed for. It boasts total vegetation control, a non-selective herbicide that can destroy every grass and weed that comes into contact with it. This gallon comes with a highly concentrated solution that can keep a large yard weed-free, killing anything growing on it.

This RM43 Total Vegetation Control contains a high concentration of Glyphosate, a hated but highly-efficient weed killer. The 43% Glyphosate makes it one of the most potent commercially available weed killers. This pack can treat vast lawn areas up to 17,297 square feet, keeping it free from vegetation.

The solution is hassle-free to use and only requires getting mixed with water and sprayed into infested lawn areas. It’s ideal for use in places that don’t require vegetation like sidewalks, fences, pathways, driveways, tennis courts, and buildings. It would also make a concentrated solution as spot-treatment in lawns and gardens infested with weeds, vines, and brushes.

Besides killing existing pesky weeds and vegetation, the RM43 43% Glyphosate solution also prevents them from coming back for at least an entire year. This weed killer is effective all-year-round but is best during late spring when weeds are actively growing.

What Can Be Improved?

As advised, the RM 43% Glyphosate is a non-selective herbicide, which can’t determine the difference between weeds and lovely rosebuds. It will kill all vegetation in the area, so it’s only ideal for use in places away from plants, vegetable gardens, and lush turf.

This solution is also a bit pricier than most herbicides, although it’s understandable because of the high Glyphosate concentration.

Roundup Weed and Grass Killer Concentrate Plus

Roundup Concentrate Plus Weed and Grass Killer - Includes...
2,370 Reviews
Roundup Concentrate Plus Weed and Grass Killer - Includes...
  • Kills tough weeds and grasses to the root
  • Rainproof in 30 minutes
  • FastAct Technology - visible results in as fast as 9 hours


  • Type – Non-selective vegetation killer
  • Capacity – 16 oz
  • Active ingredient – 18% Glyphosate, 0.73% Diquat
  • Ideal against – weeds, grasses
  • Ideal for – patios, walkways, mulch beds, gravel areas, around flowers, trees, shrubs
  • FastAct Technology; visible results within 12 hours
  • Rainproof after 30 minutes
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What We Like

Weeds and shrubs are unwanted but inevitable parts of gardens that can take over the landscape’s beauty. Fortunately, there are effective ways to kill unpleasant-looking vegetation like the potent Roundup Concentrate Plus.

It’s an authentic weed killer made with 18% Glyphosate, a proven and potent grass killer. The solution also contains Diquat Dibromide, a powerful active ingredient that can kill all weed and grass types. It’s an ideal mixture of potent chemicals to use where vegetation isn’t necessary, like driveways, patios, around trees, and along fences.

Because of its high potency, applying Roundup solution in affected areas will show results within the first 12 hours from spraying. What’s even better is the herbicide is highly efficient, rainproof within 30 minutes from application, making sure no droplet gets wasted.

Unlike other herbicides that only destroy grass leaves and stem, Roundup goes down to the roots, effectively killing pesky vegetation. Plus, one quart of this weed killer concentrate can produce up to 10 gallons of concentrated solution to cover large yards. It can get rid of tough and dense weeds and grass and prevent them from growing back.

This herbicide is a total weed killer, but it’s safe to use around humans and animals, although the proper gear is necessary to avoid inhaling the product.

What Can Be Improved?

This concentrated solution is highly potent, designed for complete removal, which is both an advantage and a drawback. While it can kill weeds and unwanted shrubs down to the roots, it can also destroy crops, flowers, vegetables, and other nearby plants. As advised, it’s best to keep edibles away from infested areas before applying this solution.

Spectracide Weed and Grass Killer Concentrate

Spectracide Weed & Grass Killer Concentrate, Use On...
4,253 Reviews
Spectracide Weed & Grass Killer Concentrate, Use On...
  • KILLS WEEDS AND GRASSES: use on driveways and walkways, and...
  • KILLS THE ROOT: visible results as fast as 3 hours –...
  • RAINFAST: rainfall or watering 15 minutes after application...


  • Type – Non-selective weed killer
  • Capacity – 64 oz
  • Coverage – 6,000 square feet
  • Coverage period – one year
  • Ideal against – weeds, grass
  • Ideal for – walkways, driveways, around trees, fences, shrubs, flower beds
  • Fast-acting; visible results within three hours
  • Rainproof and waterproof after 15 minutes
  • Ready for replanting and reseeding after one week

What We Like

When weeds start to take over the lawn and the garden, hindering other plants’ growth, it’s time to get rid of them. The Spectracide Weed and Grass Killer concentrate does a remarkable job of destroying unwanted grass and weeds in the area designed for flower beds.

It’s a non-selective weed destroyer ideal for application where there should be no vegetation like walkways, driveways, fences, and around trees.

This 64-oz concentrate is enough to make a weed killer solution to treat wide plots up to 6,000 square feet. It can kill a wide range of weed and grass types, including unwanted dandelions, clover, and poison ivy, down to the roots. Besides destroying unwanted vegetation, this solution also prevents any weed regrowth for an extended time, at least an entire year.

Besides its potency, the fast-acting performance of the Spectracide concentrate is a remarkable feature. It starts killing weeds and grass right after application, with results already visible after 3 hours. Also, the formula is impressively waterproof after 15 minutes, so that no droplet gets wasted even if it rains.

There also isn’t worry about contaminating the soil when using this weed killer. The treated area is even ready for reseeding and replanting 24 hours after application.

What Can Be Improved?

Like any other non-selective herbicide, this product has one downside, harming precious turf and nearby plants. It can kill any vegetation, so it’s not ideal for applying during windy weather.

The herbicide droplets can land on other plants and trees, which can cause damage to them too.

Spectracide Weed Killer with Extended Control Concentrate

Spectracide Weed & Grass Killer With Extended Control...
1,293 Reviews
Spectracide Weed & Grass Killer With Extended Control...
  • Size: 40 ounce
  • Concentrate
  • Prevents weeds for up to 3 months


  • Capacity – 40 oz
  • Coverage period – 3-5 months
  • Active ingredient- 2.30% Diquat
  • Ideal against – weeds, grass
  • Ideal for – driveways, walkways, patios, fences, around shrubs, trees, flowers
  • Quick-kill formula; visible results within three hours
  • Waterproof and rainproof after 15 minutes
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What We Like

Taming lawn invaders is now hassle-free and efficient using the Spectracide Weed Killer and Extended Control Concentrate. It’s a powerful solution designed to get rid of the toughest weeds and grass. This mixture can handle grasses and weeds, killing them down to the roots to avoid regrowth.

The quick-kill performance makes this concentrate worth buying, showing results three hours from the first application. But that isn’t even the most appealing part, as this weed killer can also keep the yard free from invaders for up to five months. It’s a must-have for a pristine and well-manicured lawn.

This potent formula is thanks to its active ingredient, Diquat Dibromide, a powerful chemical that can destroy all grass and weeds. It’s ideal for use in areas that require 100% no vegetation like patios, garden paths, fences, and driveways. This weed killer is also an effective patch treatment around shrubs, trees, and flower beds infested by unappealing weeds.

The formula also remains effective even after it rains. It becomes waterproof 15 minutes after application, so there are no worries about contamination to nearby plants and crops.

Overall, this concentrated herbicide is a perfect solution to keep large yards weed-free swiftly for replanting gorgeous flowers 24 hours after treatment.

What Can Be Improved?

The Spectracide weed killer is a powerful solution to kill all unwanted weeds and grass in the yard. And while it’s safe to use around most established plants, shrubs, and tree species, careful application is needed to avoid unwanted damages.

It’s essential to vacate or cover other plants and edibles before spraying this solution over infested areas.

BioAdvanced 704330A DuraZone Weed and Grass Killer

BAYER CROP SCIENCE 704330A DuraZone Weed & Grass Killer 32Oz...
248 Reviews
BAYER CROP SCIENCE 704330A DuraZone Weed & Grass Killer 32Oz...
  • KILLS and PREVENTS: Non-selective herbicide kills all...
  • 6 MONTH PROTECTION: Kills and prevents listed weeds and...
  • WEED and GRASS KILLER: Kills Crabgrass, Chickweed, Clover,...


  • Type – Non-selective weed killer
  • Capacity – 32 oz
  • Coverage – up to 1,500 square feet
  • Coverage period – six months
  • Ideal against – grass and weeds: Chickweed, Dandelion, Foxtail, Clover, Crabgrass
  • Suitable for – deck posts, driveways, stepping stones, sidewalks

What We Like

The best weed killer for large areas should handle both existing weeds and those under the ground surface.

The BioAdvanced DuraZone Weed and Grass Killer do the job efficiently as it works as both a post-emergent and pre-emergent herbicide. It can destroy weeds and unwanted shrubs already there and kill those under the surface before they can cause yard problems.

Even overgrowth and weeds up to four inches in height aren’t safe from this weed destroyer. It’s a non-selective herbicide that can eliminate all types of weeds and grass it comes in contact with, including Dandelions, foxtails, chickweed, and clover.

The solution is perfect for application in large areas using a sprayer or a hand trigger bottle for spot treatment in weed-infested yards.

Garden and yard areas that need 100% total vegetation control can benefit from this potent concentrate, including driveways, stepping stones, sidewalks, and deck posts. It only requires one application of the BioAdvance grass killer to keep the yard weed-free for 6 months.

A 32-oz bottle of this weed killer can produce four gallons of highly concentrated solution for treating the yard and getting rid of aesthetically unappealing shrubs.

What Can Be Improved?

Killing unwanted weeds is swift and efficient using the BioAdvance concentrate, but it requires careful application, especially around other plants. Like other non-selective herbicides, it kills both weeds and precious plants in the garden.

And while it’s safe for humans and pets, it’s essential to wear protective gear while spraying this all over the lawn.

Types of Weed Killer

Not all herbicides are the same, and it’s important to know that they work differently on how they kill those pesky lawn invaders.

Here are some key weed killer types to consider when buying one.

Selective Weed Killer

Selective herbicides are the type of weed killer that only targets specific plant or weed species. They are the safest to use around flower and vegetable gardens as they don’t harm nearby plants or the turf.

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Non-Selective Weed Killers

Non-selective herbicides are the type that will kill everything in its wake, which includes all weeds, grass, plants, flowers, shrubs, and even tree leaves. It’s safe to use this type of weed killer, but it requires extreme caution to avoid nearby vegetation.

Pre-Emergent Weed Killers

This type of herbicide targets weeds from below the surface, eliminating the cause of chaos before they can grow and infest the lawn. For pre-emergent weed killers to work, you should have an idea of where to apply it best.

Post-Emergent Weed Killers

This type of herbicide is the ideal solution for treating yards and gardens where weeds are already visible and growing. It’s the common herbicide to use for existing weed problems in the lawn.

Systemic Weed Killers

Systemic herbicides are the type that slowly but surely kills weeds. This weed killer requires for the plants to absorb it so it can destroy them down to the roots, preventing any regrowth and another infestation.

Contact Weed Killers

This type of herbicide will only destroy the plant’s parts that come into contact with the solution. It is usually fast-acting, but won’t be enough to kill stubborn weeds and grass. Contact weed killers cause the weed leaves to dry out, but the roots remain intact, causing them to grow back shortly.

Types of Weed Killer

What to Consider When Buying a Weed Killer for Expansive Lawns?

Each weed killer has distinct characteristics, and it’s essential to consider several factors before purchasing the best weed killer for large areas.

Purpose: Prevention vs. Cure

One primary consideration is the purpose of the purchase. Choose a pre-emergent herbicide when the job requires the prevention of weed problems in the lawn. Meanwhile, a post-emergent herbicide is a better choice for curing or treating yards already infested by weeds.

Types of Weeds and Area of Application

Herbicides are not the same, and some are better at getting rid of specific weed and grass species than others. It would help to identify what kind of weeds or grass are there to find a weed killer that is strong enough to destroy it.

Non-selective weed killers are usually the safest option for killing unknown weeds as they can get rid of most types of vegetation.

Size of Area

The gallon of herbicide doesn’t usually mean it can cover more expansive plots of land. It always comes down to the chemical concentration of the weed killer. Highly concentrated herbicides will only need a small amount to mix with a gallon of water, making it more ideal for treating large areas.

Determine how wide the area that needs treatment is and find a weed killer to cover that expanse.

Active Ingredients

It’s also worth considering what active ingredients are there in the weed killer solution. While other chemicals effectively kill weeds and grass, they can also be harmful to humans and animals. Some can also contaminate the soil, which could damage the growth of existing plants.

There are also active ingredients in herbicides that can compromise the immune system or are toxic when inhaled. Besides an effective weed killer, safety should again come first and foremost.

Glyphosate is a common active ingredient in herbicides, considered as the most effective weed killer. Also, Diquat Dibromide is a potent chemical that can get rid of all weed and grass types.


It’s also worth considering how long the weed killer will be useful in suppressing weed growth. Some herbicides can keep the yard weed-free for a couple of months up to an entire year.

Also, fast-acting herbicides can be a bonus, especially if it has long-lasting effects.

Application Method

The application methods will also matter when choosing the best weed killer for large areas. Most are in granule form while others are liquid and need to dilute in water before spraying to infected areas. Diluted herbicides using a sprayer are the most ideal for treating large lawns.

What to Consider When Buying a Weed Killer for Expansive Lawns?


The RM43 is impressively concentrated with Glyphosate, making it highly potent to kill all types of weeds and grasses. It can keep the entire yard weed-free for at least a year, making it worth buying to keep the lawn pristine and healthy.

Still, looking for the best weed killer for large areas will depend on several factors, including the application area, the purpose of treatment, and weed types.

Last update on 2024-02-27 / Affiliate links / Images from Amazon Product Advertising API

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Jill Sandy

I am a sustainable focus gardener. I love decorating my home backyard with beautiful landscape design and creative garden care techniques I develop myself.